P-glycoprotein (MDR1, ABCB1)
P-glycoprotein (MDR1, ABCB1) – the prototypic polyspecific ABC-transporter When in 1976 Juliano and Ling discovered that the main difference between a wild type tumour cell and a multidrug resistant tumour cell is a glycosylated transmembrane protein which reduces the accumulation of cytotoxic agents in the cell, this marked the beginning…
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