Leveraging linked open data by use of innovation leading technologies.

At Phenaris we constantly challenge the status quo in computational drug design and in silico toxicology.

Using cutting edge technologies we provide data, models, and decision support in all aspects of in silico toxicology. We are currently working on multiple solutions to provide data integration, model development, and decision support.

Data Integration

DATA INTEGRATION

In the era of big data, data curation and integration is an absolute requirement for approaching complex research questions. Being part of large scale, industry driven data integration initiatives, we offer our expertise in this area.

Model Development

MODEL DEVELOPMENT

High quality predictive toxicity models are needed to support risk assessment. Based on high quality data, we provide a set of models for transporter and toxicity endpoints, which are constantly kept up to date.

Decision Support

DECISION SUPPORT

Prioritizing the right compounds is key for successful drug development. Our integrated toxicologcal read across platform supports decision making in all phases of drug discovery. This does not only save time and money, but also animal experiments.

For more information please visit our products and services pages.

Latest News

Webinar Recording: Transporter Models V2

On November 24th, 2020 we held a webinar on the recently released version 2 of our Transporter Models. The webinar was recorded, so you can rewatch if you missed it. With the addition of three new transporter, we are now offering models for 9 transporter (P-glycoprotein, BCRP, BSEP, MRP3, OATP1B1,[…]

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Transporter Models Version 2 released

Transmembrane Transport Proteins (TMTs) control nutrient uptake, ion transport, and drug transport across biological membranes. Predicting substrate and inhibition profiles of small molecules towards these transporters helps medicinal chemists to prioritize compounds in an early phase of the drug development process and guide toxicologists in the safety assessment of candidate[…]

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P-glycoprotein (MDR1, ABCB1)

P-glycoprotein (MDR1, ABCB1) – the prototypic polyspecific ABC-transporter When in 1976 Juliano and Ling discovered that the main difference between a wild type tumour cell and a multidrug resistant tumour cell is a glycosylated transmembrane protein which reduces the accumulation of cytotoxic agents in the cell, this marked the beginning[…]

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